Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 4
2010 4
2011 1
2012 2
2014 2
2019 1
2021 1
2022 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Results by year

Filters applied: . Clear all
Page 1
Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages.
Mimae T, Okada M, Hagiyama M, Miyata Y, Tsutani Y, Inoue T, Murakami Y, Ito A. Mimae T, et al. Clin Cancer Res. 2012 Feb 15;18(4):945-55. doi: 10.1158/1078-0432.CCR-11-1946. Epub 2011 Dec 21. Clin Cancer Res. 2012. PMID: 22190591
We then immunohistochemically investigated the presence of candidate molecules in 64 samples of advanced adenocarcinoma and statistically analyzed the findings, together with clinicopathologic variables. RESULTS: The transcription factors Notch2 and Six1 were upregulated i …
We then immunohistochemically investigated the presence of candidate molecules in 64 samples of advanced adenocarcinoma and statistically an …
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
Wang CA, Jedlicka P, Patrick AN, Micalizzi DS, Lemmer KC, Deitsch E, Casás-Selves M, Harrell JC, Ford HL. Wang CA, et al. J Clin Invest. 2012 May;122(5):1895-906. doi: 10.1172/JCI59858. Epub 2012 Apr 2. J Clin Invest. 2012. PMID: 22466647 Free PMC article.
Using a mouse mammary carcinoma model, we found that VEGF-C was not sufficient to mediate all the metastatic effects of SIX1, indicating that SIX1 acts through additional, VEGF-C-independent pathways. Finally, we verified the clinical significance of this prometasta …
Using a mouse mammary carcinoma model, we found that VEGF-C was not sufficient to mediate all the metastatic effects of SIX1, indicat …
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition.
McCoy EL, Iwanaga R, Jedlicka P, Abbey NS, Chodosh LA, Heichman KA, Welm AL, Ford HL. McCoy EL, et al. J Clin Invest. 2009 Sep;119(9):2663-77. doi: 10.1172/JCI37691. Epub 2009 Aug 24. J Clin Invest. 2009. PMID: 19726883 Free PMC article.
The neoplastic lesions induced by Six1 had an in situ origin, showed diverse differentiation, and exhibited progression to aggressive malignant neoplasms, as is often observed in human carcinoma of the breast. ...We further show that Six1 promoted a stem/prog …
The neoplastic lesions induced by Six1 had an in situ origin, showed diverse differentiation, and exhibited progression to aggressive …
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth.
Micalizzi DS, Wang CA, Farabaugh SM, Schiemann WP, Ford HL. Micalizzi DS, et al. Cancer Res. 2010 Dec 15;70(24):10371-80. doi: 10.1158/0008-5472.CAN-10-1354. Epub 2010 Nov 5. Cancer Res. 2010. PMID: 21056993 Free PMC article.
However, the mechanism by which Six1 impinges on the TGF-beta pathway was, until now, unclear. In this work, we identify the TGF-beta type I receptor (TbetaRI) as a target of Six1 and a critical effector of Six1-induced TGF-beta signaling and EMT. ...Interest …
However, the mechanism by which Six1 impinges on the TGF-beta pathway was, until now, unclear. In this work, we identify the TGF-beta …
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling.
Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Barón AE, Harrell JC, Horwitz KB, Billheimer D, Heichman KA, Welm AL, Schiemann WP, Ford HL. Micalizzi DS, et al. J Clin Invest. 2009 Sep;119(9):2678-90. doi: 10.1172/JCI37815. Epub 2009 Aug 24. J Clin Invest. 2009. PMID: 19726885 Free PMC article.
TGF-beta signaling and EMT have been implicated in metastatic dissemination of carcinoma. Accordingly, we used spontaneous and experimental metastasis mouse models to demonstrate that Six1 overexpression promotes breast cancer metastasis. In addition, we show that, …
TGF-beta signaling and EMT have been implicated in metastatic dissemination of carcinoma. Accordingly, we used spontaneous and experiment …
Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.
Chu Y, Chen Y, Li M, Shi D, Wang B, Lian Y, Cheng X, Wang X, Xu M, Cheng T, Shi J, Yuan W. Chu Y, et al. Cancer Sci. 2019 Jul;110(7):2200-2210. doi: 10.1111/cas.14033. Epub 2019 May 29. Cancer Sci. 2019. PMID: 31050834 Free PMC article.
However, the specific role and the underlying mechanism of Six1 in leukemia maintenance remain unexplored. Here, we showed increased expression of SIX1 in AML patients and murine leukemia stem cells (c-Kit(+) cells, LSCs). ...Further analysis revealed the augmented …
However, the specific role and the underlying mechanism of Six1 in leukemia maintenance remain unexplored. Here, we showed increased …
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression.
Micalizzi DS, Farabaugh SM, Ford HL. Micalizzi DS, et al. J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):117-34. doi: 10.1007/s10911-010-9178-9. Epub 2010 May 19. J Mammary Gland Biol Neoplasia. 2010. PMID: 20490631 Free PMC article. Review.
For example, developmental EMT regulators including Snail/Slug, Twist, Six1, and Cripto, along with developmental signaling pathways including TGF-beta and Wnt/beta-catenin, are misexpressed in breast cancer and correlate with poor clinical outcomes. ...
For example, developmental EMT regulators including Snail/Slug, Twist, Six1, and Cripto, along with developmental signaling pathways …
Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1.
Ng KT, Lee TK, Cheng Q, Wo JY, Sun CK, Guo DY, Lim ZX, Lo CM, Poon RT, Fan ST, Man K. Ng KT, et al. Int J Cancer. 2010 Aug 15;127(4):859-72. doi: 10.1002/ijc.25105. Int J Cancer. 2010. PMID: 20013809 Free article.
In this study, short hairpin RNA (shRNA) interference approach was used to suppress the expression of Six1 in a metastatic HCC cell line MHCC97L. Stable transfectant MHCC97L-shSix1 carrying Six1-specific shRNA plasmid was established to downregulate Six1 expr …
In this study, short hairpin RNA (shRNA) interference approach was used to suppress the expression of Six1 in a metastatic HCC cell l …
Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression.
Gartin AK, Frost TC, Cushman CH, Leeper BA, Gokhale PC, DeCaprio JA. Gartin AK, et al. J Invest Dermatol. 2022 Oct;142(10):2783-2792.e15. doi: 10.1016/j.jid.2022.03.008. Epub 2022 Mar 22. J Invest Dermatol. 2022. PMID: 35331717 Free PMC article.
Furthermore, we show the EZH2 inhibitor tazemetostat slows the growth of MCC xenografts and derepresses SIX1 and its downstream inner ear transcriptional target MYO6 in vivo. We propose that EZH2 inhibition in MCC leads to SIX1 derepression with dysregulation of hea …
Furthermore, we show the EZH2 inhibitor tazemetostat slows the growth of MCC xenografts and derepresses SIX1 and its downstream inner …
Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis.
Radisky DC. Radisky DC. J Clin Invest. 2009 Sep;119(9):2528-31. doi: 10.1172/JCI40555. Epub 2009 Aug 24. J Clin Invest. 2009. PMID: 19726879 Free PMC article.
In this issue of the JCI, McCoy and colleagues show that transgenic mice that express the homeoprotein Six1 in mammary epithelial cells show increases in stem/progenitor cell populations and subsequent tumor development, while in a separate study Micalizzi and colleagues s …
In this issue of the JCI, McCoy and colleagues show that transgenic mice that express the homeoprotein Six1 in mammary epithelial cel …
14 results